Specific Structural Features of Heparan Sulfate Proteoglycans Potentiate Neuregulin-1 Signaling
نویسندگان
چکیده
منابع مشابه
Specific structural features of heparan sulfate proteoglycans potentiate neuregulin-1 signaling.
Neuregulins are a family of growth and differentiation factors that act through activation of cell-surface erbB receptor tyrosine kinases and have essential functions both during development and on the growth of cancer cells. One alternatively spliced neuregulin-1 form has a distinct heparin-binding immunoglobulin-like domain that enables it to adhere to heparan sulfate proteoglycans at key loc...
متن کاملHeparan sulfate proteoglycans.
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions. Here, we discuss changing views on the specificity of protein-heparan sulfate binding and the activity of HSPGs as receptors and core...
متن کاملHeparan sulfate proteoglycans
Studies of the involvement of ECM molecules in cell attachment, growth, and differentiation have revealed a central role of heparan sulfate (HS) proteoglycans (HSPGs) in early embryogenesis, morphogenesis, angiogenesis, and epithelial-mesenchymal interactions (1–3). HS chains bind a multitude of proteins and ensure that a wide variety of bioactive molecules (e.g., heparin-binding growth factors...
متن کاملSpecific structural features of syndecans and heparan sulfate chains are needed for cell signaling.
The syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of the syndecan core proteins has a short cytoplasmic domain that binds cytosolic regulatory factors. The syndecans also contain highly conserved transmembrane domains and extrac...
متن کاملRole of heparan sulfate proteoglycans in cell signaling and cancer.
The correct growth and development of multicellular organisms depends on the reception of numerous extracellular signals that activate various signal transduction cascades within the target cells. The activity of these pathways, such as the receptor tyrosine kinases (RTKs), transforming growth factor-β (TGF-β), Wnts, and Hedgehogs (Hh), are usually regulated by the binding of extracellular liga...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m402645200